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Effect of Strontium Substitution on the Bioactive Properties and Structure of Borate-Based Bioglass

Chen Yang, Bo Jia, Fei Wang, Yufei Wang, Wenbo Yang, Li Liang

Journal of Ceramic Science and Technology, Vol. 16, No. 4 (2025), pp. 247-254

DOI: 10.4416/JCST2025-00004

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Abstract

Borate-based bioglass has attracted keen interest as a bone repair material owing to its good machinability and degradability, but the quick release of boron can lead to cytotoxicity and this is an issue that needs to be taken into consideration. In this paper, borate-based bioglass scaffolds substituted with 0 – 9 mol% strontium with a porous microstructure were prepared by means of a polymer foam replication technique. The effect of the strontium substitute on the bioactive properties and structure of the scaffolds was investigated by means of XRD, SEM, MTT, FTIR and MAS-NMR testing. The results showed that the as-made bioglass was amorphous and had a porous microstructure similar to human trabecular bone. The in vitro bioactivity of the glass was observed based on the conversion of the glass surface to a nanostructured hydroxyapatite layer in SBF. The substitution of strontium in borate-based bioglass keeps the concentration of B3+ ions in a more acceptable[GS1]  range. According to the Fourier transform infrared and MAS-NMR spectra, when the strontium increased, part of the silicate network structure in the glass is destroyed. Meanwhile, the layer structure containing [BO3] is gradually replaced by the framework structure containing [BO4], this is the basic reason why the bioactive properties of the borate-based glass changed with the strontium substitution.

Keywords

Borate-based bioglass, strontium, bioactive properties, structure

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