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Development of Novel ZnO-Doped Hydroxyapatite Polycarboxylate Dental Cement
Y. E. Greish1, S. H. Kenawy2, S. I. Habib3, T. A. Moussa3, H. A. Shalaby4, M. El Deftar 5
1 Department of Chemistry, Faculty of Science, United Arab Emirates University, Al Ain, United Arab Emirates
2 Department of Chemistry, Faculty of Science, Jazan University, Saudi Arabia
3 Biomaterials Department, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt
4 Biomaterials Department, Misr International University, Cairo, Egypt
5 Tissue Culture and Cytogenetics Unit, National Cancer Institute, Cairo University, Cairo, Egypt
received July 2, 2011, received in revised form August 12, 2011, accepted August 26, 2011
Vol. 2, No. 4, Pages 227-236 DOI: 10.4416/JCST2011-00022
Abstract
Calcium phosphate cements (CPCs) have been clinically used for the past fifteen years in different hard-tissue-related applications. The end-product of a set CPC is normally a hydroxyapatite (Ca10(PO4)6(OH)2; HAp), which has structural and morphological similarity to the mineral part in these hard tissues. Similar to ceramic materials, CPCs have the disadvantage of being brittle, which limits their applications to non-load bearing applications. The addition of a ductile ingredient, such as biocompatible polymers, has been suggested as a reasonable avenue to solve these problems. The current study deals with the development of a novel cement comprising CPC with polyacrylic acid (PAA) in addition to ZnO as an accelerator. The physical, structural, mechanical, and biological performance of this cement has been evaluated. Results showed that two types of cements could be used in which dried or calcined HAp represents the CPC constituent of the cement, and that the addition of 20 – 30 % by weight of ZnO showed enhanced properties compared to ZnO-free cements. The enhanced reactivity of calcined HAp with PAA, compared to that of dried HAp, was reflected in a more stable non-toxic cement that is highly recommended as a potential bone/dental cement, and which is characterized by its high bioactivity.
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Keywords
Hydroxyapatite, dental cement, polycarboxylate, in vitro performance, stem cells
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